Ancient Egyptian pyramids, thought to contain only the elite, may also hold low-class laborers
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At the
site of Tombos, archaeologists have found that less-affluent laborers
may be buried with upper-class people in pyramid tombs.
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Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling
Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling A Murashima-Suginami 1 , H Kiso 1 , Y Tokita 2 , E Mihara 3 , Y Nambu 4 , R Uozumi 5 , Y Tabata 6 , K Bessho 1 , J Takagi 3 , M Sugai 7 8 , K Takahashi 9 Affiliations Expand PMID: 33579703 PMCID: PMC7880588 DOI: 10.1126/sciadv.abf1798 Abstract Uterine sensitization-associated gene-1 ( USAG-1 ) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG...
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