Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling A Murashima-Suginami 1 , H Kiso 1 , Y Tokita 2 , E Mihara 3 , Y Nambu 4 , R Uozumi 5 , Y Tabata 6 , K Bessho 1 , J Takagi 3 , M Sugai 7 8 , K Takahashi 9 Affiliations Expand PMID: 33579703 PMCID: PMC7880588 DOI: 10.1126/sciadv.abf1798 Abstract Uterine sensitization-associated gene-1 ( USAG-1 ) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG...
Scientists make disturbing discovery in Miami's rainwater: 'What happens in one area can impact here, there, everywhere' Story by Leslie Sattler Rain in Miami has a disturbing secret: It's carrying toxic "forever chemicals" that can harm people and wildlife, per reports by Phys.org. These synthetic substances, known as PFAS , are hitching a ride on raindrops and spreading far beyond their source, according to research from Florida International University. See Full Story here
Boeing Starliner astronauts will return to Earth in March 2025 after new NASA, SpaceX delay By Josh Dinner That's one month later than previously planned. The astronaut duo who flew the first-ever crewed mission of Boeing's Starliner capsule will have to wait a little longer to rejoin us on Earth . The next crew rotation mission to the International Space Station (ISS), SpaceX's Crew-10, has been delayed to no earlier than late March 2025, NASA announced on Tuesday (Dec. 17). Crew-10 was originally slated to fly in February , but it has been pushed back to allow time for SpaceX to complete work on a brand-new Crew Dragon spacecraft for the mission, NASA said in a statement on Tuesday. The delay means at least an extra month aboard the ISS for the astronauts of SpaceX's Crew-9 flight, who won't depart the orbital laboratory until after Crew-10's arrival. You may like Will Boeing's Starliner astronauts ri...
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