Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling

 

Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling

A Murashima-Suginami 1, H Kiso 1, Y Tokita 2, E Mihara 3, Y Nambu 4, R Uozumi 5, Y Tabata 6, K Bessho 1, J Takagi 3, M Sugai 7 8, K Takahashi 9
Affiliations 

Abstract

Uterine sensitization-associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti-USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti-USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy.

PubMed Disclaimer


Similar articles

See all similar articles

Cited by

See all "Cited by" articles
See the original story here

Comments

Post a Comment

Popular posts from this blog

Scientists make disturbing discovery in Miami's rainwater: 'What happens in one area can impact here, there, everywhere'

  Scientists make disturbing discovery in Miami's rainwater: 'What happens in one area can impact here, there, everywhere' Story by Leslie Sattler Rain in Miami has a disturbing secret: It's carrying toxic "forever chemicals" that can harm people and wildlife, per  reports  by Phys.org. These synthetic substances,  known as PFAS , are hitching a ride on raindrops and spreading far beyond their source, according to research from Florida International University. See Full Story here
Read more

Boeing Starliner astronauts will return to Earth in March 2025 after new NASA, SpaceX delay

  Boeing Starliner astronauts will return to Earth in March 2025 after new NASA, SpaceX delay By  Josh Dinner That's one month later than previously planned. The astronaut duo who flew the first-ever crewed mission of Boeing's Starliner capsule will have to wait a little longer to rejoin us on  Earth . The next crew rotation mission to the  International Space Station  (ISS), SpaceX's Crew-10, has been delayed to no earlier than late March 2025, NASA announced on Tuesday (Dec. 17). Crew-10 was originally  slated to fly in February , but it has been pushed back to allow time for  SpaceX  to complete work on a brand-new  Crew Dragon  spacecraft for the mission,  NASA  said in  a statement  on Tuesday. The delay means at least an extra month aboard the ISS for the astronauts of SpaceX's Crew-9 flight, who won't depart the orbital laboratory until after Crew-10's arrival. You may like Will Boeing's Starliner astronauts ri...
Read more